occasionally my attacks stop responding.

After a monster dies to a particular skill, even releasing the mouse button and re-clicking with a new monster targeted will not cast until a different skill is cast.

For example monster dies with freezing pulse, freezing pulse stops responding completely until I cast ice spear. Also it seems like a movement action allows me to cast again as well. The problem seems intermittent, but annoying when manifested.

Yes, this is happening to me constantly. I thought it was my mouse failing, but it only recently started happening after the new patch.

My middle button especially isn't registering 75% of the time. Or i click on a monster and I don't do anything. Also, once i couldn't move and had to log out.

It doesn't affect movement as much as attacking, but clicking on monsters doesn't register 70% of the time when i use frenzy which is linked to my scroll botton. I just randomly stop attacking with frenzy too when it does register, or i can't attack a monster with frenzy at all sometimes. No matter how many times i click, frenzy most times just doesn't register.

left click and right click work fine most of the time, but sometimes when i try to move by left clicking i can't. My character just stands there, then i have to click several times before he does anything.

I've been noticing it tonight in Beta when I throw down my first Fire Trap. The next throw often doesn't seem to register, and I have to try again, or even twice more. ='[.]'=

It happens to me too! I use freezing pulse too! Maybe its the spell?

I have had similar when using skills on the middle mouse button.

I don't know if my problem is similar, but my character stops attacking when monster that you target with mouse is out of side (for example, behind the wall close to a doorway or behind the rock). This start to happen after the patch. I use Ethereal Knives.

Have the same problem with Freezing Pulse, don't know if it happens with other skills though.

same, freezing pulse on middle mouse button. Glad it's not just me, dangerous glitch has almost cost me my (in game) life several times.

In my case it happens when there is some kind of obstacle around the cursor and the target, like wall, tree. I also have noticed that my character stops attack when my coursor near items text name on the ground or near walls in some places like Vaal Pyramid and Im targeting a monster. I use right mouse button.