A BIG Thank You to the POE community for inspiring me to work harder

I'm a long time POE player, off and on since we used to farm Peity runs. I always liked the game, but more so - I liked the community. From toxic people on global who hand out savage insults but also help with items and builds, to helpless noobs who PC chaos orbs - the POE community has brought me much joy through the years. Even that nameless bird with the huge beak (GET DOWN!) made me smile.
Five years ago I started researching Parkinson's disease and luckily enough for me, I contracted the disease - which made the research so much easier to do. It also made it harder to play, which is unfortunate. People have helped me out so much, I could never thank you guys enough!
When I started researching Parkinson's disease, I never ever EVER in a million years thought I would find anything significant. I just thought I would learn more about the condition and it was something I always wanted to look into as a kid and adult. With Covid, I got my chance to do an investigation. I got that sweet fat and juicy unemployment in the US which allowed me to devote 12-20 hours a day to my inquiry into the cause and origin of PD.
After 15,0000+ hours of studying the condition, I believe I have unlocked the mystery. Parkinson's is a very unusual disease with many perplexing components. Below are the top 10 mysteries of Parkinson's that no one has had an answer for.

#1 Why was PD first discovered and described in 1817?
#2 Why were the first cases of PD originally found in London?
#3 Why do doctors, nurses and certain health care workers have the highest rates of PD?
#4 Why does PD have such a wide-ranging spectrum and high number of seemingly unrelated symptoms?
#5 Why do smokers have significantly less PD than non-smokers?
#6 Why are Parkinson's diagnosis rates rising sharply year after year?
#7 Why are more younger people getting PD year after year?
#8 Why does Australia have the highest and China the lowest PD rates?
#9 Why do Rosacea and Parkinson's have such a high comorbidity?
#10a Why is delusional parasitosis found so frequently Parkinson's patients?
#10b Why do people who report delusional parasitosis often later develop Parkinson's and other Neurological diseases?

There is one single 7 word answer that explains all 10 of the above unexplained questions above:
Parkinson's is caused by an organism from Australia.
#1 The first appearance of PD was not until 1817 because the disease did not, in theory, exist outside of Australia. Parkinson's was not extant in historical medical literature dating back thousands of years and across dozens of cultures, save for a very small number of isolated reports of patients with varyingly similar symptoms. Dr. Parkinson's high degree of perspicacity and incredibly acute perception enabled him to detect the disease by observing the local population. Seamen and travelers to and from Australia brought back the organism responsible for PD starting with the colonization of Australia by Britian.

#2 The description and discovery were in London, by Dr. James Parkinson, as that was the travel hub for travelers to and from Australia. This also explains why Jean-Martin Charcot was presented with PD patients in Paris 50 years later. This is because the organism responsible went first from Australia to London and then from London to Paris. in 1869 Dr, Charcot was the first person to describe and diagnose what today we call ALS. Like PD, it too was unknown in the world prior to the mid 1800's. These two (and many, many more) 'diseases' are actually symptoms caused by the organism(s) brought back to London from Australia.

#3 Doctors, nurses and certain other health care workers have the highest PD incidence rates, by occupation than any other profession. The higher education one possesses, the higher the risk of PD, and this has left researchers puzzled fir decades. The cause is of course, that medical staffers see, treat, touch and interact primarily with the sick, injured or dying has never been seriously considered or investigated. These patients bring the organism with them and they infect the clinicians and staff when they are treated. The organism responsible for Parkinson's causes many other cryptogenic diseases as well as many other conditions that doctors classify as 'auto-immune' diseases is readily transmitted from casual touching of surfaces and interaction between patients and medical staff.

#4 Parkinson's disease, including Atypical Parkinson's, manifests itself in a wide range of unusual symptoms and effects on the body. Those afflicted by PD have a broad spectrum of seemingly unrelated and variable symptoms. These symptoms are diverse and their correlation to each other has baffled researchers. The more common motor symptoms of PD include the following: Stiffness, slow movement or freezing up (bradykinesia) and tremor. Many other PD patients report additional symptoms. 90% of patients experience non-motor symptoms including the following: sleeping irregularities with insomnia and fatigue while awake, skin irritation, mood changes, muscle pain, constipation, Bruxism (grinding one's teeth while asleep) and mild to moderate weight loss.
Now compare those symptoms of PD, to symptoms typically reported by Parasitosis sufferers: Insomnia and fatigue, skin diseases with irritation and itchiness, Psychiatric effects including confusion, intermittent psychosis, delirium, anxiety and mood swings along with depression, muscle pain and weakness, constipation and diarrhea, Bruxism and weight loss.
Nearly every secondary symptom of Parkinson's is also a symptom of parasitosis. While no single list of secondary PD symptoms matches an exact list of parasitosis symptoms, cross referencing the data by alternating inputs from "XXX Parkinson's symptom" with "XXX Parasitosis symptom" will yield 95% affinity between the two.

#5 Just as occupation and location are correlated to risk of Parkinson's, so too are numerous other factors. One of the correlations that is found most baffling by researchers is the fact that cigarette and cigar smokers have considerably less incidences of PD than non-smokers. This is true even when using adjusted earlier death rates of smokers among the two groups, and factoring in education and profession. In addition to the numerous studies that demonstrate that PD rates are markedly lower in cigarette smokers than the general population, studies also show that this inverse relationship between smoking and PD is dose dependent. That is, the more a person smokes, the less of a chance that he or she will develop PD. Another study investigated identical twin pairs in which one had PD and the other did not. The twin without PD tended to smoke more than the twin with PD. Since identical twins share the same DNA and often the same environment, many of the variables normally associated with a difference in risk of PD were removed – except for smoking. This is because tobacco contains chemicals including nicotine, which are strongly antiparasitic, serve as insecticides and have antifungal properties. Smoking inhibits growth of the organism that causes Parkinson's resulting in the significantly lower PD incidence rates seen between smokers and non-smokers.

#6 PD diagnosis is becoming more and more common throughout the world. A study in 2012 found PD incidence rates, based on smaller studies, were estimated to be in the 40,000 – 60,000 range per year. A 2022 study showed the new incidence rate is 1.5 times higher at nearly 90,000 cases annually in the USA. In the United Kingdom the lifetime risk of being diagnosed with Parkinson's disease is 2.7%. This is equivalent to 1 in every 37 people being diagnosed at some point in their lifetime. The PD prevalence rate has grown more than 50% in the span of five years. Not only are more people getting PD, the rate of the rise itself is also rising. The reason more people are being diagnosed with PD is that more people are carriers of the organism that causes it.

#7 The average age of a person receiving a Parkinson's diagnosis is now 57, down from 60 years of age in less than a decade. Diagnosis of PD by a patient younger than 50 is classified as 'early onset' Parkinson's. Once it was exceedingly rare for a person under 50 to contract PD, but now approximately 14% of U.S. Parkinsons's cases in the commercially insured population occur in adults younger than 50 years of age. This is also true with Alzheimer's and dementia diagnoses. The reason for this is that the infection by the organism generally takes an estimated 12- 25 years before it has done enough damage to cause the more common symptoms. Babies are now being born infected or being exposed to the organism at birth resulting in younger and younger ages at diagnosis. A decade ago, it was thought that the youngest age at which a person could get Parkinson's was their late teens, but last year, a two year old toddler became the youngest person in history to be diagnosed with PD.

#8 Parkinson's is known throughout most of the world. Different countries and regions of the world have different rates of diagnoses of PD. Some nations have more or less than others. Notably, Australia has the highest incidence rate of PD per capita and China has the lowest. Note that I am referring to diagnosed per capita incidences and not deaths attributed to Parkinson's and that this inquiry is focused on industrialized nations. China had the largest increase in age-adjusted prevalence rates for PD between 1990 and 2016. This is because China is the one of the largest industrialized nations on earth whose population -until recently- did the least travelling. With the advent of Chinese prosperity, many more of it's citizens were able to travel for pleasure and other purposes, becoming carriers of the parasite as in the course of their travel to other industrialized nations where PD was more well established. Australia of course has the highest rates as the organism is native to Australia.

#9 Rosacea and Parkinson's are strongly linked and Rosacea constitutes an independent risk factor for Parkinson disease, and vice versa. Researchers in 2023 speculated that "up to 30%" of Rosacea cases are caused by parasites, and research is ongoing. The organisms that can be seen on PD patients and Rosacea patients alike, is also present in a vast number of patients with other diseases who show clear signs of infection by this organism.

#10a A significant cohort of PD patients report parasitic infestation, which doctors call 'Delusional parasitosis' as there are no parasites visible to doctors. Neary all doctors are of a belief that it is not possible for a patient to have a parasite unknown to medical profession. In fact I have discussed this topic with researchers and some doctors as well -some of whom treated me when I was their patient- who have essentially said "We don't know what causes Parkinson's but we know it isn't a parasite." Parasitosis as a potential cause of Parkinson's is not now, nor has ever been seriously considered or studied in the modern era. With billions of dollars spent on research and treatment of Parkinson's every year and the immense daily suffering by those afflicted, one could somewhat reasonably assume that researchers have 'left no stone unturned' in a search for the cause. Sadly this is not true. Much of their error stems from a disease description and diagnosis that dates back to 1937. In that year, Dr. Karl-Axel Ekbom a phycologist, was treating a patient that complained of parasitosis. He presumably inspected the patient and, finding nothing, decided that the patient was suffering a delusional parasitosis. Interestingly enough, like PD, more men are diagnosed with delusional parasitosis than women, and the average age at diagnosis is 57 years.

#10b people without PD who report (delusional) parasitosis in many cases, later go on to later develop PD. The etiology and pathophysiology of delusional parasitosis are unknown but a significant percentage of PD patients are affected by the belief that they have an infestation. I have examined photographs of patients who were diagnosed with delusional parasitosis, often called Ekbom's syndrome, and found that they bear clear and unmistakable signs of the organism found on many PD patients.


This is a rough draft only and this is the first time I have shared my research. I have 2TB of images from my microscope and photos of PD patients. I look forward to sharing more with the world this week.
The POE community and the game itself have brought me solace and spurred me on to do better, THANK YOU!
Just today, a POE player REALLY went over the top helping me out. I refer to him as Richard the enjoyer of cheese, but his character name is the shorter name of Richardcheeseenjoyer :D His kindness to a stranger (me) really makes me want to do better, and I will.
Thanks to Path of Exile players! I hope to open the eyes of the world to what I have found - and playing POE has helped me relax when not working and taken the bite out of the disease!

Special thanks to all my friends! C, E, J and Dandi from Thailand!

i ll just say i m happy for you to have these good interactions! keep up your efforts

Thanks exsea! Every bit of support is welcomed I am publishing my full research this week. I have 10K + images of the organism I believe responsible.
People would be fools to believe me, but the world would be a bigger fool not to investigate my claims.
Mine is the first ever theory to answer any of the top ten questions, let alone all ten with just one answer.
Occam's Razor states that:
a scientific and philosophical rule that entities should not be multiplied unnecessarily which is interpreted as requiring that the simplest of competing theories be preferred to the more complex or that explanations of unknown phenomena be sought first in terms of known quantities.
TLDR: “Occam's razor, or the principle of parsimony, tells us that the simplest, most elegant explanation is usually the one closest to the truth.”
I have 15,000 hours into my study pf PD and the "theory or parasitosis" only occupies 2500 of that. The rest is in experiments, microscopy and treatment.
I successfully gave myself PD and also have removed most of the organisms from my body, much damage was done however to my body and brain that I fear is irreversible. That is one of the reasons I am publishing before my inquiry is complete. When you see it in the news, you can be like "I gave that dude props in his thread" TYVM Bro

no probs!

i see no reason to be needlessly negative and to be honest im tired of seeing it. so when i see someone excited because of something positive, i share the joy and rejoice that someone made your day a little more brighter.

cheers!

Thanks for sharing this. You present some very interesting information.

As a clinician, I have never heard of any infection protocols regarding Parkinson's, and I have certainly had a number of such patients, including those with atypical presentation.

Parkinson's has a lot of potential etiologies. As for infectious causes/contributory factors to Parkinson's, there's a nice article from
Frontiers in Neurology June 2019
Infectious Etiologies of Parkinsonism: Pathomechanisms and Clinical Implications
authors: Nattakarn Limphaibool,* Piotr Iwanowski, Marte Johanne Veilemand Holstad, Dominik Kobylarek, and Wojciech Kozubski



I would question the origin of Parkinson's in Australia, as descriptions suggestive of Parkinson's have been found from India in 1000 BC and ancient Chinese sources, as well as being described by Dutch scientist Sylvius de la Boë in 1680

You can read more on this in the article from
Cold Spring Harbor Perspectives in Medicine Sep 1, 2011
The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies
author: Christopher G. Goetz


Another brief article (2 pages) discusses potential mentions of Parkinson's throughout history Including that Leonardo da Vinci speculated and wrote about it before 1500 and that Rembrandt's sketch of The Good Samaritan depicts Parkinson's:

the innkeeper in Rembrandt's sketch "The Good Samaritan" of 1630 is
"in an attitude which can only befound in one who has
constant tremor so that ... he really seems to shake".



This information was published in
Journal ofNeurology, Neurosurgery, and Psychiatry
Special Supplement 1989:11-12
Did Parkinsonism occur before 1817?
author: Gerald Stern



I am always refreshed by how resilient people often are in spite of the various challenges that life throws at them.