Can no longer use the left mouse button

This just happened today in the silo map level 15. I use lacerate of hemorrhage and suddenly it started spamming uncontrollably during game play. After about a minute it stopped but it will no longer work. I can move the skill to another mouse button or key and will work. Anything that i try to map to the left key mouse will not work.
I can still click on items w/ the left button....it just wont link up to a skill any longer.

Looked at the options window ....and the left mouse button is greyed out and can not be edited. Other buttons are editable and work as they are supposed to. No idea if i hit some key on the keyboard as i was using the same key layout during gameplay. Never had this issue before. Other games are fine....however my other characters in poe are all affected.

ok..now its working again. Only thing i did was move 'attack in place' to the spacebar and close all user interface to the shift button and saved it.
now it works? No idea what it was or if this fixed it. Never touched those 2 before until after my attack left mouse button stopped working today. Weird