{TIPS} D4 was useful for at least something. Invert your mouse clicks!

Preface, Enjoying the hell out of POE2, even as a melee where some people may be complaining about the early game workrate, even though I took like 2 hrs to finish the Act 1 boss as a lvl 17 ice monk but whatever xD

When it comes to Keyboard+Mouse and high intensity inputs/mechanics, even with WASD, clicking for a whole day was maybe getting to my arm/hands again...I just thought to remember to drink a lot of water, stretches, whatever...

BUT

Then I learned what I did from being a fast attacking archer for the whole month on release d4 before I quit that crap, that constant left mouse clicking is stressful as hell on your arm.

Right clicking priority resolves it!
(IE using your main attacks, picking up, npc selecting etc on right clicking)

It makes your arm+hand lean slightly more to the right side, so you're not twisting so much at the end. I use a simple app called X-Mouse button control to simply set anything I want for the mouse, including inverting the left and right mouse clicks. Even if you're very young I think you should do it and as you won't get as much problems in the future!

.
To end, I found it strange the keybinds for this game (map, passives, skills in general) but I found it strange that there wasn't an "invert mouse clicks", which D4 actually had!
Anyway, good luck with your health everybody! ^^